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| Advisor(s) | apt. Angga Nugraha Sanjaya, S.Farm., M.Farm. | |
| Author(s) | putri, Elisa amelia | |
| Issued Date | 2026 | |
| Abstract | STAPHYLOCOCCUS EPIDERMIDIS IS ONE OF THE BACTERIA THAT CAN CAUSE INFECTION AND TRIGGER AN INFLAMMATORY RESPONSE IN TISSUES. GREEN TEA LEAVES (CAMELLIA SINENSIS L.) ARE KNOWN TO CONTAIN SECONDARY METABOLITE COMPOUNDS THAT POTENTIALLY HAVE ANTIBACTERIAL AND ANTI-INFLAMMATORY ACTIVITIES. THIS STUDY AIMED TO DETERMINE THE ANTIBACTERIAL EFFECTIVENESS OF ETHANOL EXTRACT OF GREEN TEA LEAVES (CAMELLIA SINENSIS L.) AGAINST STAPHYLOCOCCUS EPIDERMIDIS IN VITRO, TO DETERMINE THE ANTI-INFLAMMATORY ACTIVITY IN VIVO ON THE PAWS OF MALE WHITE RATS (RATTUS NORVEGICUS) INDUCED BY STAPHYLOCOCCUS EPIDERMIDIS, AND TO DETERMINE THE MOST EFFECTIVE EXTRACT CONCENTRATION. EXTRACTION WAS PERFORMED USING THE MACERATION METHOD WITH 96% ETHANOL SOLVENT. THE ANTIBACTERIAL TEST WAS PERFORMED USING THE DISK DIFFUSION METHOD AT EXTRACT CONCENTRATIONS OF 30%, 40%, AND 50%, WITH AMOXICILLIN AS THE POSITIVE CONTROL AND AQUADES AS THE NEGATIVE CONTROL. THE ANTI-INFLAMMATORY TEST WAS PERFORMED ON MALE WHITE RATS INDUCED BY STAPHYLOCOCCUS EPIDERMIDIS BY COMPARING THE GROUP GIVEN 50% ETHANOL EXTRACT OF GREEN TEA LEAVES WITH THE GROUP GIVEN AMOXICILLIN. THE PHYTOCHEMICAL SCREENING RESULTS SHOWED THAT THE ETHANOL EXTRACT OF GREEN TEA LEAVES WAS POSITIVE FOR ALKALOIDS, FLAVONOIDS, SAPONINS, TANNINS, AND STEROIDS. THE ANTIBACTERIAL TEST RESULTS SHOWED THAT THE AVERAGE INHIBITION ZONE DIAMETERS AT CONCENTRATIONS OF 30%, 40%, AND 50% WERE 15.68 ± 0.84 MM, 17.85 ± 0.39 MM, AND 19.07 ± 0.26 MM, RESPECTIVELY, WHILE THE POSITIVE CONTROL PRODUCED AN INHIBITION ZONE DIAMETER OF 20.38 ± 0.16 MM. THE ANTI-INFLAMMATORY TEST RESULTS SHOWED THAT THE 50% ETHANOL EXTRACT OF GREEN TEA LEAVES WAS ABLE TO REDUCE THE PAW EDEMA VOLUME OF RATS INDUCED BY STAPHYLOCOCCUS EPIDERMIDIS. BASED ON THE STUDY RESULTS, IT CAN BE CONCLUDED THAT THE ETHANOL EXTRACT OF GREEN TEA LEAVES (CAMELLIA SINENSIS L.) HAS ANTIBACTERIAL ACTIVITY AGAINST STAPHYLOCOCCUS EPIDERMIDIS AND IN VIVO ANTI-INFLAMMATORY ACTIVITY, WITH A CONCENTRATION OF 50% SHOWING THE BEST EFFECTIVENESS IN THIS STUDY. SUGGESTIONS FOR FUTURE RESEARCH ARE TO TEST THE ANTI-INFLAMMATORY ACTIVITY OF ETHANOL EXTRACT OF GREEN TEA LEAVES USING SEVERAL CONCENTRATION VARIATIONS AND MORE SPECIFIC INFLAMMATION PARAMETERS, SO THAT THE MOST EFFECTIVE CONCENTRATION AND ITS ANTI-INFLAMMATORY ACTIVITY CAN BE DETERMINED IN GREATER DEPTH | 1 |
| Item Type | Skripsi | |
| Keywords | Camellia sinensis L., antibakteri, antiinflamasi, Staphylococcus epidermidis, ekstrak etanol. | 1 |
| Collection | Fakultas Farmasi, S1-Farmasi | |
| Publisher | INSTITUT KESEHATAN DELI HUSADA | |
| Submitted Date | 22-10-2026 | |
| Updated Date | 22-10-2026 | |
| URI | https://repo.delihusada.ac.id/handle/123456789/11257 | |
| File |
2218055_ELISAAMELIAPUTRI_SKRIPSI_S1.pdf
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