Informasi ringkas dokumen repository.
| Advisor(s) | Tarigan, Ratna Sari Putri br | |
| Author(s) | GALINGGING, ADETIA SANITA BR | |
| Issued Date | 2026 | |
| Abstract | Bay leaf (Syzygium polyanthum) is a plant widely found in Indonesia and contains secondary metabolites with potential antibacterial activity. This study aimed to determine whether bay leaf ethanol extract could be formulated into an anti-acne patch, evaluate its antibacterial activity against Propionibacterium acnes and Staphylococcus aureus, and determine the most effective extract concentration in inhibiting the growth of both bacteria. This study used an experimental method. Bay leaf extract was obtained by maceration using 96% ethanol and formulated into anti-acne patches containing 15% (F1), 20% (F2), and 25% (F3) extract. The preparations were evaluated for organoleptic properties, pH, thickness, weight uniformity, and folding endurance. Antibacterial activity was tested using the disc diffusion method, with N’Pure as the positive control and the preparation base as the negative control. The results showed that all formulations met the physical evaluation requirements. Antibacterial activity increased with increasing extract concentration. The F3 formulation (25%) showed theost effective antibacterial activity, with average inhibition zone diameters of 19.50 mm against Propionibacterium acnes and 13.66 mm against Staphylococcus aureus. Statistical analysis showed a significant difference among the treatment groups (p<0.05). In conclusion, bay leaf ethanol extract can be formulated into an anti-acne patch and exhibits antibacterial activity against Propionibacterium acnes and Staphylococcus aureus, with F3 (25%) being the most effective formulation. Further research is recommended to develop other topical dosage forms, expand extract concentration variations, conduct stability and safety testing, and investigate specific flavonoid compounds such as quercetin and kaempferol. | 1 |
| Item Type | SKRIPSI | |
| Keywords | Patch antiacne,(Anti-acne patch), Daun Salam (Syzygium polyanthum), (Bay leaf (Syzygium polyanthum)),Antibakeri,(Antibacterial), Propionibacterium acnes, (Propionibacterium acnes), Staphylococcus aureus,(Staphylococcus aureus) | 1 |
| Collection | Fakultas Farmasi, S1-Farmasi | |
| Publisher | INSTITUT KESEHATAN DELI HUSADA | |
| Submitted Date | 04-09-2026 | |
| Updated Date | 05-09-2026 | |
| URI | No URI | |
| File |
2218003_ADETIASANITABRGALINGGING_SKRIPSI_S1 (1) (1).pdf
Login untuk Preview
|
|